Status:
UNKNOWN
Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives.
Lead Sponsor:
Erasmus Medical Center
Collaborating Sponsors:
Dutch Kidney Foundation
Pfizer
Conditions:
Hyperaldosteronism
Hypertension
Eligibility:
All Genders
18-65 years
Brief Summary
This study aims to evaluate the diagnostic value of the Aldosterone-Renin Ratio (ARR)as a screening test for primary aldosteronism among hypertensives. The test characteristics will be studied. Furthe...
Detailed Description
Although primary aldosteronism (PA) was formerly seen as a rare cause of hypertension, this condition is now thought to be the commonest cause of secondary hypertension, with the prevalence ranging up...
Eligibility Criteria
Inclusion
- age 18-65 years
- blood pressure above 140 mmHg systolic and above 90 mmHg diastolic
- use of at least 2 antihypertensive drugs
Exclusion
- known cause of hypertension, including white-coat hypertension
- severe renal failure (kreat \> 200 umol/l)
- BMI above 32 kg/m2
- poorly regulated diabetes mellitus (HbA1C \> 8.0 %)
- heart failure
- stroke or myocardial infarction within 6 months before inclusion
- angina pectoris
- pregnancy
- neoplastic disease, within 5 years before inclusion
- alcohol abuse
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
End Date :
November 1 2009
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT00407784
Start Date
January 1 2007
End Date
November 1 2009
Last Update
March 7 2007
Active Locations (13)
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1
Academical Medical Center
Amsterdam, Netherlands
2
VU medical Center
Amsterdam, Netherlands
3
IJsselland Hospital
Capelle aan den IJssel, Netherlands
4
Beatrix Hospital
Gorinchem, Netherlands