Status:
COMPLETED
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney Disease
Lead Sponsor:
Carolina Cannillo
Conditions:
Polycystic Kidney, Autosomal Dominant
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The aim of the study is to test the following hypotheses: 1. that the function and/or regulation of AQP2 and /or ENaC in the principal cells is abnormal in autosomal dominant polycystic kidney diseas...
Detailed Description
Recruitment: The patients with ADPKD are recruited from the Outpatient Nephrology Clinic of the Department of Medicine, Holstebro Hospital (Holstebro, Denmark). The control subjects are recruited by ...
Eligibility Criteria
Inclusion
- Caucasian men and women
- age 18-65 years
- BMI between 18,5-30,0 kg/m2
- ADPKD, diagnosed by the following findings on ultra scan:
- for patients without ADPKD family history: \> 5 bilateral cysts
- for patients with ADPKD family history: \< 30 years: 2 cysts (unilateral or bilateral) 30-60 years: 2 or more bilateral cysts \> 60 years: 4 or more bilateral cysts
- Kidney function: stadium 1-4.
Exclusion
- Other kidney disease
- Anamnestic or clinical signs of acute myocardial infarction, atrial fibrillation, heart valve disease or chronic heart failure
- Anamnestic or clinical signs of disease in lungs, liver,endocrine organs or brain or neoplastic disease
- Family history of rupture of intracerebral aneurisms
- Alcohol or drug abuse
- Smoking
- Medical treatment arat form antihypertensives and oral anticonceptives
- Pregnancy or breastfeeding
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2011
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT00410007
Start Date
October 1 2006
End Date
November 1 2011
Last Update
March 20 2018
Active Locations (1)
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1
Department of Medical Research, Holstebro Hospital
Holstebro, Denmark, 7500