Completed
Efficacy of Silymarin for Treatment of Acute Hepatitis In Egypt: A Randomized, Double-Blinded, Controlled Trial
Led by University of Maryland, Baltimore · Updated on 2021-04-23
200
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall objective of this project is to assess whether Silymarin therapy shortens illness or prevents complications in patients with acute hepatitis. We will specifically compare responses in acute hepatitis patients treated with Silymarin to those given a control preparation of a vitamin supplements in a double blinded, randomized, placebo-controlled trial.
CONDITIONS
Brief Title
Efficacy of Silymarin for Acute Hepatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients admitted to the fever hospital and presenting with symptoms and signs that may be consistent with a diagnosis of acute hepatitis.
- Recent (<1 month) history of illness.
- Elevation of ALT > 2.5 normal.
- At least 13 years old.
You will not qualify if you...
- History suggestive of severe drug-induced acute hepatitis.
- Children 12 years and younger.
- Pregnant or breastfeeding women
- Suspected hypersensitivity to Silymarin or vitamin preparations.
- Evidence of advanced liver disease e.g. history or presence of ascitis, bleeding esophageal varices, and hepatic encephalopathy.
- Patients who are critically ill, with multisystem failure or cancer.
- Substance abuse such as IV drugs.
- Any other conditions, which in the opinion of the investigator would make the patient unsuitable for enrollment or could interfere with the patient's participation in and completion of the protocol.
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
0
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