Status:
COMPLETED
Exercise Training, Insulin Resistance and Coronary Artery Disease
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Collaborating Sponsors:
Hamilton Health Sciences Corporation
Canadian Diabetes Association
Conditions:
Coronary Artery Disease
Glucose Intolerance
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study was to determine the effects of exercise training on insulin resistance in subjects with coronary artery disease independent of changes in weight, diet, or the effect of an a...
Detailed Description
Objectives To determine the effects of exercise training on insulin resistance in CAD subjects without diabetes, independent of changes in weight, diet, or the effect of acute exercise. The study was...
Eligibility Criteria
Inclusion
- men and women over 18 years of age
- fasting plasma glucose concentration 5.4-7.7 mmol/L
- confirmed CAD (diagnosed on the basis of a previous myocardial perfusion study or cardiac catheterization, or a history of a myocardial infarction or coronary artery angioplasty or coronary artery bypass surgery).
Exclusion
- known type 1 or 2 diabetes
- clinical heart failure
- uncorrected significant valvular or congenital heart disease
- significant obstructive pulmonary disease (forced expiratory volume in 1 sec / forced vital capacity \< 0.5)
- uncontrolled hypertension (blood pressure \> 220 / 120 mm Hg)
- participation in a regular exercise program within the preceding three months
- inability to perform exercise training, atrial fibrillation
- a permanent pacemaker
- regularly used corticosteroid
- recent (\< 3 months) myocardial infarction, unstable angina, coronary artery bypass graft surgery, or coronary artery angioplasty
- run-in phase fasting blood glucose was \< 5.4 mmol/L or \> 11.1 mmol/L at 2 hours following the 75 gram oral glucose load.
Key Trial Info
Start Date :
November 25 1998
Trial Type :
INTERVENTIONAL
End Date :
June 9 2000
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00412815
Start Date
November 25 1998
End Date
June 9 2000
Last Update
August 28 2017
Active Locations (1)
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1
Hamilton Health Sciences Centre
Hamilton, Ontario, Canada, L8L2X2