Status:
COMPLETED
MRI of Alzheimer's Disease Imaging Amyloid Plaques in Persons With and Without Memory Problems
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
55-90 years
Brief Summary
The study will investigate the possibility of detecting early signs of Alzheimer's disease using magnetic resonance imaging (MRI). If plaques, types of damage, can be imaged by MRI, the procedure coul...
Detailed Description
Objective: The objective of the proposed pilot study is to investigate the possibility of detecting early signs of Alzheimer's Disease (AD) using high field (7T) MRI. If plaques can be imaged by MRI,...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Any neurologically and psychiatrically normal, male or female, healthy volunteer ages 55-90 years old. Participants must be capable of understanding the procedures and requirements of this study and subjects must be willing to sign an informed consent document. Normal controls will demonstrate normal function in daily life, based on the Clinical Dementia Rating Scale (CDR). The CDR is administered annually to all JHADRC participants.
- AD patients will be required to meet the NINCDS/ADRDA criteria for AD. All patients must be mildly impaired. Severity will be measured by the Mini-Mental State Exam (MMSE) and only patients with an MMSE score of 20 - 26 will be included. They must be able to give informed consent.
- EXCLUSION CRITERIA:
- Inability to cooperate.
- A subject will be excluded if he/she has a contraindication to MR scanning such as the following: claustrophobia, pregnancy, aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant; ocular foreign body (e.g. metal shavings) or insulin pump.
- Subjects who underwent brain surgery, or other neurological disease (e.g., stroke, Parkinson's disease, significant brain vascular disease, brain trauma).
- Evidence of cerebrovascular risk factors, including diabetes, arrhythmias, and lacunar infarcts seen on MRI.
- History of vertigo, seizure disorder, middle-ear disorder, and double vision.
- Active major psychiatric illness.
- Dental work such as ferromagnetic crowns or bridges.
Exclusion
Key Trial Info
Start Date :
December 14 2006
Trial Type :
OBSERVATIONAL
End Date :
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00413621
Start Date
December 14 2006
Last Update
July 2 2017
Active Locations (2)
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1
Johns Hopkins University
Baltimore, Maryland, United States, 21205
2
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892