Status:
COMPLETED
Effects of tDCS Over the Cerebellum on Motor Function
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Healthy
Eligibility:
All Genders
18-40 years
Brief Summary
This study will evaluate whether applying electrical stimulation on the cerebellum (posterior and lower part of the brain) can influence brain excitability and hand movement performance. A new techni...
Detailed Description
Objectives Non-invasive brain stimulation can modulate motor function in healthy volunteers and stroke patients when applied over the primary motor cortex (M1). M1 is an evident target for therapeuti...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- age between 18-40 years
- able to perform tasks required by the study
- willing and able to give consent
- EXCLUSION CRITERIA:
- unable to perform the tasks required by the study
- history of severe alcohol or drug abuse, psychiatric illness like severe depression, or severe language disturbances, particularly of receptive nature or with serious cognitive deficits (defined as equivalent to a mini-mental state exam score \[MMSE\] of 23 or less), or degenerative brain processes such as Alzheimer's disease
- severe uncontrolled medical problems (e.g., cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease, or a deteriorated condition due to age, uncontrolled epilepsy or others), more than moderate to severe microangiopathy, polyneuropathy, diabetes mellitus, or ischemic peripheral disease
- problems with movement of the hands
- receiving drugs acting primarily on the central nervous system, which lower the seizure threshold, such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants (for the TMS component only)
- pregnant (for the MRI component only)
- medical or technical contraindications to MRI procedures or devices producing artifacts that impair MRI signal (e.g., pacemakers, implanted medication pumps, cochlear devices, neural stimulators, metal in the cranium, surgical clips, and other metal/magnetic implants, claustrophobia)
Exclusion
Key Trial Info
Start Date :
December 14 2006
Trial Type :
OBSERVATIONAL
End Date :
August 20 2008
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00413842
Start Date
December 14 2006
End Date
August 20 2008
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892