Status:
COMPLETED
Comparison of the Effect of 4th Generation Fluoroquinolones, Gatifloxacin and Moxifloxacin, on Epithelial Healing Following Photorefractive Keratectomy (PRK), A Substudy of: Initial Evaluation of Excimer Laser Keratorefractive Surgery in U.S. Army Personnel (WU # 2335-99)
Lead Sponsor:
Walter Reed Army Medical Center
Conditions:
Epithelium, Corneal
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
The purpose of this study is a prospective,double-blinded, randomized trial to compare the rate of healing following PRK after the use of two commercially available 4th generation fluoroquinolones, mo...
Eligibility Criteria
Inclusion
- Manifest refraction spherical equivalent (MSE) of up to -6.00 diopters (D) at the spectacle plane with refractive cylinder up to 3.00D.
Exclusion
- Concurrent topical or systemic medications that may impair healing including corticosteroids, antimetabolites, isotretinoin, amiodarone hydrochloride and/ or sumatripin.
- Patients with known sensitivity or inappropriate responsiveness to any of the medications used in the post-operative course.
- Anterior basement membrane dystrophy.
- History of recurrent epithelial erosion.
- Significant dry eye (symptomatic sith Schirmer \<5mm at 5 minutes)
- Other corneal epithelial disorder or healing abnormality
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2005
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00414011
End Date
February 1 2005
Last Update
July 17 2013
Active Locations (1)
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1
Walter Reed Army Medical Center
Washington D.C., District of Columbia, United States, 20307