Status:
COMPLETED
Stroke in Young Fabry Patients (sifap1): Frequency of Fabry Disease in Young Stroke Patients
Lead Sponsor:
CENTOGENE GmbH Rostock
Collaborating Sponsors:
Shire Human Genetic Therapies, Inc.
Conditions:
Cerebrovascular Accident
Eligibility:
All Genders
18-55 years
Brief Summary
More than one million people in Europe suffer from a stroke every day. Normally older people have a stroke, but also a significant number of younger people between 18 and 55 years. Usually, these cann...
Detailed Description
Aim: To determine the frequency of Fabry disease in an unselected group of young patients (18 - 55 years of age) with acute cerebrovascular event (CVE) Fabry disease and stroke: Rolfs and co-worker...
Eligibility Criteria
Inclusion
- Adult patients (18 - 55 years of age) with an acute cerebrovascular event of any etiology defined as patients having an acute ischemic stroke or transient ischemic attack less than 3 months before enrollment into the study
- MRI-scan evidence of associated corresponding brain infarction or hemorrhage, regardless of the duration of symptoms. Alternatively also patients with no signs of stroke in the MRI can be included if a stroke-experienced neurologist has done the initial diagnosis as ischemic stroke, transient ischemic attack or hemorrhage.
- Detailed MRI documentation at admission to entry to the study
- Diagnostic procedures for CVE according to the EUSI recommendations
- Written informed consent from patient or legal representative according to local regulations
Exclusion
- Patients being younger than 18 years or older than 55 years of age.
- Acute ischemic stroke or transient ischemic attack longer than 3 months before enrolment into the study
- Diagnosis of the CVE within the last 3 months has been done by a non-neurologist if there is no MRI-scan evidence of associated brain infarction or hemorrhage
- No detailed MRI documentation at admission to entry to the study
Key Trial Info
Start Date :
January 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2010
Estimated Enrollment :
5000 Patients enrolled
Trial Details
Trial ID
NCT00414583
Start Date
January 1 2008
End Date
January 1 2010
Last Update
April 9 2021
Active Locations (45)
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1
Universitätsklinikum für Neurologie
Graz, Austria, A-8036
2
Department of Neurology, Universitaetsklinik fuer Neurologie Innsbruck
Innsbruck, Austria, 6020
3
Wagner-Jauregg Linz, Department of Neurology
Linz, Austria, A-4020
4
Christian-Doppler-Klinik, Department für medizin. Studien
Salzburg, Austria, 5020