Status:
UNKNOWN
Prevention Of Morbidity In Sickle Cell Disease Pilot Phase
Lead Sponsor:
Institute of Child Health
Conditions:
Sickle Cell Anaemia
Eligibility:
All Genders
4-16 years
Phase:
PHASE2
Brief Summary
The hypothesis is that in sickle cell anaemia, nocturnal oxyhaemoglobin desaturation, is associated with low processing speed index, and this morbidity can be reduced with overnight auto Continuous Po...
Detailed Description
Intervention: Overnight auto Continuous Positive Airways Pressure (CPAP) with oxygen supplementation if mean overnight oxyhaemoglobin saturation is not \>94% after 2 weeks of autoCPAP
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age \>4 years.
- Informed consent with assent in accordance with UK ethical committee(COREC) system must be signed by the patient's parent or legally authorized guardian acknowledging written consent to join the study. When suitable, patients will be requested to give their assent to join the study.
- Haemoglobin SS (homozygous sickle cell anaemia) diagnosed by standard techniques. Participating institutions must submit documentation of the diagnostic haemoglobin analysis.
Exclusion
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00415727
Start Date
November 1 2006
Last Update
December 25 2006
Active Locations (2)
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1
Neuroscience Unit, Institute of Child Health
London, United Kingdom, WC1N 1EH
2
Kings College hospital
London, United Kingdom, WC2R 2LS