Status:
COMPLETED
Combined High Frequency Oscillation and Tracheal Gas Insufflation for Severe Acute Respiratory Distress Syndrome
Lead Sponsor:
University of Athens
Conditions:
Respiratory Distress Syndrome, Adult
Eligibility:
All Genders
18-75 years
Phase:
PHASE1
PHASE2
Brief Summary
In the past five years, there is a growing body of published evidence on the feasibility, and oxygenation and lung protection benefits of high frequency oscillation (HFO) in the acute respiratory dist...
Detailed Description
OBJECTIVES AND UNDERLYING HYPOTHESIS High frequency oscillation (HFO) has beneficial physiological effects in acute respiratory distress syndrome (ARDS) \[1-4\]. A recent randomized controlled trial ...
Eligibility Criteria
Inclusion
- Early Acute Respiratory Distress Syndrome
- PaO2/FiO2 \< 150 mm Hg at PEEP ≥ 8 cm H2O
- Age 18-75 years
- Body weight \> 40 kg
Exclusion
- More than 1 chest tube/hemithorax with persistent airleak for \> 72 h)
- Systolic pressure \< 90 mm Hg with fluids/norepinephrine at ≥ 0.5 μg/kg/min
- Heart disease (defined in Detailed Description)
- Chronic obstructive pulmonary disease (defined in Detailed Description)
- Intracranial abnormalities (any cause of intracranial pressure \> 20 mm Hg)
- Chronic interstitial lung disease
- Lung biopsy or resection on current admission
- Previous lung or bone marrow transplant or immunosuppression
- Pregnancy or morbid obesity
- Inability to wean from prone positioning or inhaled nitric oxide
- Enrollment in another interventional study
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2007
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT00416260
Start Date
July 1 2006
End Date
September 1 2007
Last Update
June 24 2014
Active Locations (1)
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1
Evaggelismos General Hospital
Athens, Attica, Greece, GR-106 75