Status:
COMPLETED
Validation of MRI Measurement of Cardiac Blood Flow
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
21+ years
Brief Summary
This study will test the accuracy of magnetic resonance imaging (MRI) in measuring cardiac perfusion (blood flow). MRI of the heart can measure blood flow to heart muscle, but collateral coronary arte...
Detailed Description
Cardiac magnetic resonance imaging (MRI) can measure perfusion (blood flow) to heart muscle. Collateral coronary arteries (natural bypasses to the heart) may reduce the accuracy of perfusion measured ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients with known or suspected cardiovascular disease
- Age above age 21 (coronary artery disease is rare in subjects less than age 21)
- Undergoing medically necessary coronary arteriography
- Written informed consent
- The subject must allow access to the use of previous medical information from NIH or any institution in order to participate in the research study.
- EXCLUSION CRITERIA:
- Medical Exclusion Criteria:
- Pregnant women (when uncertain, subjects will undergo urine or blood testing) or lactating women
- Decompensated congestive heart failure (unable to lie flat during MRI or catheterization)
- Impaired renal excretory function (calculated Glomerular Filtration Rate less than 30mL/min/1.73m(2)) unless on dialysis.
- MRI Exclusion Criteria (for MRI scan only):
- Cardiac pacemaker or implantable defibrillator
- Cerebral aneurysm clip
- Neural stimulator (e.g. TENS-Unit)
- Any type of ear implant
- Ocular foreign body (e.g. metal shavings)
- Any implanted device (e.g. insulin pump, drug infusion device)
- Metal shrapnel or bullet.
- Unable to tolerate dipyridamole:
- Reactive airways disease (significant asthma or chronic obstructive pulmonary disease and unable to tolerate a beta adrenergic antagonist).
- Post-Hoc Catheterization Exclusion Criteria (determined during coronary arteriography):
- Excessive tortuosity or any angiographic features that, in the opinion of catheterization operator, would make invasive physiology assessments unsafe or unsuitable
- Ongoing myocardial ischemia or other exigency that would make further study participation hazardous
- Normal epicardial coronary arteries and normal perfusion cardiac MRI
Exclusion
Key Trial Info
Start Date :
December 29 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 19 2010
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00417625
Start Date
December 29 2006
End Date
July 19 2010
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892