Status:
COMPLETED
Detecting a Reward Signal in the Motor Cortex
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Healthy
Eligibility:
All Genders
18-60 years
Brief Summary
This study will use transcranial magnetic stimulation (TMS) to determine whether the activity in the brain when someone wins something affects the part of the brain that controls movement. Studies hav...
Detailed Description
Objectvie: The role of mesencephalic dopamine neurons in reward processing has been established in primates using electrophysiological techniques and in humans using functional neuroimaging. Their ro...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Men and women, age 18-60.
- EXCLUSION CRITERIA:
- Significant neurological or psychiatric history.
- History of habitual gambling, defined as either visiting casinos more than once per month or playing cards for money more than once per week or gambling over the internet more than once per month.
- Habitual consumption of more than two drinks a day, marijuana more than once a week or any other illicit drug use within the last three months.
- Use of medication affecting the DA system, such as phenothiazine antihistamines (promethazine), antiemetics or decongestants within the last month.
- Seizure History.
- Significant abnormality on neurological examination.
- Metal in the cranial cavity or eye, pacemaker, implanted pumps or stimulators.
- Subjects who have participated in experiments 1-5 in this protocol may not participate in experiment 6, or 7.
Exclusion
Key Trial Info
Start Date :
January 8 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 6 2014
Estimated Enrollment :
168 Patients enrolled
Trial Details
Trial ID
NCT00422071
Start Date
January 8 2007
End Date
March 6 2014
Last Update
December 17 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892