Status:
COMPLETED
Genetics of Middle Ear Disease
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Otitis Media
Eligibility:
All Genders
Brief Summary
The goal of this study is to identify the genes that contribute to susceptibility to recurrent/persistent middle ear disease. Five hundred families with at least 2 children who have undergone tympanos...
Detailed Description
Using the twin study approach, the investigators demonstrated that time with middle ear effusion (MEE), number of episodes of MEE and numbers of episodes of acute otitis media (AOM) have a strong gene...
Eligibility Criteria
Inclusion
- families: 2 or more full sibs who had tympanostomy tubes inserted
Exclusion
- major congenital malformations
- medical conditions with a predisposition for OM (e.g. cleft palate, Down syndrome, or other craniofacial malformations
- cared for in the Intensive Care Unit as neonate
- been on assisted ventilation
- known sensorineural hearing loss
Key Trial Info
Start Date :
July 1 2002
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
2121 Patients enrolled
Trial Details
Trial ID
NCT00422136
Start Date
July 1 2002
End Date
July 1 2009
Last Update
November 14 2017
Active Locations (1)
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1
ENT Research Center, Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, United States, 15224