Status:
COMPLETED
Collection of Heart Tissue Sample During Open Heart Surgery
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Ischemia
Eligibility:
All Genders
18-80 years
Brief Summary
This study will collect heart tissue that is routinely removed and discarded during open-heart surgery. The Cardiology Branch of the NHLBI is conducting a variety of laboratory experiments that requir...
Detailed Description
Transient non-lethal ischemia followed by reperfusion activates a cell survival program resulting in increased tolerance to subsequent ischemic injury. This biological phenomenon is termed ischemic pr...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Subjects must be 18-80 years of age.
- Subjects must provide informed, written consent to donate tissue that would otherwise be discarded post-cardiac surgery.
- Subjects undergoing elective coronary artery bypass surgery and or aortic valve replacement surgery.
- EXCLUSION CRITERIA:
- Subjects currently on oral sulfonylurea therapy for diabetes mellitus
- Subjects in atrial fibrillation or having had a history of atrial fibrillation in the 2-week period prior to surgery
- Subjects in clinical right heart failure as evidenced by greater than trace pedal edema, an elevated JVP and or by evidence of hepatic congestion.
- Subjects unable to give informed consent
Exclusion
Key Trial Info
Start Date :
January 11 2007
Trial Type :
OBSERVATIONAL
End Date :
December 10 2007
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00423553
Start Date
January 11 2007
End Date
December 10 2007
Last Update
July 2 2017
Active Locations (1)
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1
Suburban Hospital
Bethesda, Maryland, United States, 20814