Status:
TERMINATED
Effects of Intensive Long-Term Vasodilation in Hypertensive Patients With Microvascular Angina Pectoris
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Danish Cardiovascular Research Academy
Danish Heart Foundation
Conditions:
Microvascular Angina
Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine if long-term vasodilatory treatment is more effective than the standard treatment in hypertensive patients with microvascular angina pectoris
Detailed Description
Patients with hypertension frequently develop angina pectoris. This can be caused by either epicardial stenotic disease or, equally frequent, by increased resistance in small resistance vessels - micr...
Eligibility Criteria
Inclusion
- hypertension
- angina pectoris CCS class II-IV
- objective signs of ischemia on exercise-ECG or myocardial SPECT
- no significant stenosis on angiography (minimal lumen diameter \>50% of relevant reference segment)
Exclusion
- known allergy to any study medication
- abnormal lab tests of clinical significance
- valvular disease of haemodynamic significance
- known secondary hypertension
- atrial fibrillation or other significant arrythmias
- myocardial infarction \< 30 days before inclusion
- resting angina \< one week before inclusion
- known endocrine disease, nephropathy or hepatic disease
- present malignant disease
- pregnancy
- fertile women not using safe contraceptives \> 6 months before inclusion. Use of contraceptives must continue 1 month after completion or retraction from the study
- body mass index \> 30
- significant chronic obstructive lung disease (FEV1 \< 1.5 l)
- participant in another study including test medicine
- present treatment with dipyridamole
- present treatment with phosphodiesterase-5-inhibitors that the patient does not want to discontinue during the study period
- heart transplanted patients
- patients with magnetizable metallic implants
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00424801
Start Date
January 1 2007
End Date
December 1 2008
Last Update
May 6 2009
Active Locations (1)
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1
Aarhus Hospital
Aarhus, Denmark, 8000