Status:

COMPLETED

Ketosis Prone Diabetes in African-Americans

Lead Sponsor:

Emory University

Conditions:

Ketosis Prone Diabetes

Diabetic Ketoacidosis

Eligibility:

All Genders

19-65 years

Brief Summary

Over 50% of obese African-Americans (AA) presenting with newly diagnosed, severe hyperglycemia and/or unprovoked diabetic ketoacidosis (DKA) display clinical, metabolic, and immunogenetic features of ...

Detailed Description

More than half of obese African-Americans (AA) with newly diagnosed diabetes presenting with diabetic ketoacidosis (DKA) display clinical, metabolic, and immunogenetic features of type 2 diabetes duri...

Eligibility Criteria

Inclusion

  • 36 Obese AA subjects with DKA or severe hyperglycemia and 8 obese nondiabetic subjects, age 19-65. All studies will be performed in the GCRC at Grady Memorial Hospital.
  • Subjects with a BMI ≥ 28 kg/m2 will be included.
  • Diagnostic criteria for DKA will include:
  • a plasma glucose \> 250 mg/dl,
  • a venous pH \< 7.30,
  • a serum bicarbonate \< 18 mEq/l, and
  • high serum ketones.
  • Obese hyperglycemic patients will have:
  • a blood glucose on admission \> 400 mg/dl,
  • a serum bicarbonate \> 18 mEq/l, and
  • negative ketones.

Exclusion

  • Patients with significant medical or surgical illness, including but not limited to myocardial ischemia, congestive heart failure, chronic renal insufficiency, liver failure, and infectious processes;
  • Patients with recognized endocrine disorders, such as hypercortisolism, acromegaly, or hyperthyroidism;
  • Bleeding disorders, or abnormalities in coagulation studies;
  • Pregnancy.

Key Trial Info

Start Date :

May 1 2007

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

August 1 2010

Estimated Enrollment :

44 Patients enrolled

Trial Details

Trial ID

NCT00426413

Start Date

May 1 2007

End Date

August 1 2010

Last Update

November 13 2013

Active Locations (1)

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Page 1 of 1 (1 locations)

1

Grady Memorial Hospital

Atlanta, Georgia, United States, 30303