Status:
COMPLETED
A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
Lead Sponsor:
James J. Peters Veterans Affairs Medical Center
Conditions:
Orthostatic Hypotension
Spinal Cord Injury
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
With upright postures, there is an immediate redistribution of blood to the dependent circulation; venous return and central venous filling pressure are reduced, resulting in diminution of cardiac out...
Detailed Description
In individuals with SCI, blood pressure regulation is altered compared to the non-SCI population and relates to the degree of sympathetic vascular denervation. The inadequate release of norepinephrine...
Eligibility Criteria
Inclusion
- This study will be performed on subjects 18 to 65 years old, with chronic SCI (\> 1 year), who are neurologically stable and have demonstrated significant hypotension (total time \[proportion 50%\] spent with hypotension \[systolic BP below 110 mmHg for males and 100 mmHg for females\] during a 24-hour observation.
Exclusion
- hypertension
- diabetes
- vascular disease
- cardiac disease
- cardiovascular medication
- pregnancy
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT00426842
Start Date
January 1 2007
End Date
March 1 2011
Last Update
October 10 2016
Active Locations (1)
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1
VA Medical Center, Bronx
The Bronx, New York, United States, 10468