Status:
COMPLETED
Effect of Eplerenone on Endothelial Function in Patients With Stable Coronary Heart Disease
Lead Sponsor:
University of Zurich
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
30-80 years
Brief Summary
The aim of the present study is to investigate wether endothelial dysfunction associated with stable coronary artery disease is altered by selective aldosterone antagonism with Eplerenone as potential...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Male patients (\> 30 years of age) with history of coronary artery disease (documented by coronary angiogram, nuclear imaging, positive stress test)
- Stable cardiovascular medication for at least 4 months Evaluation of the patients will take place at the Department of Internal Medicine, Cardiology, University Hospital Zurich.
- Exclusion criteria:
- Evidence for myocardial infarction, unstable angina, stroke within 3 months prior to study entry
- coronary intervention/re-vascularisation procedure within 3 months prior to study entry
- long acting nitrates
- uncontrolled arterial hypertension, defined as RR\>160/90 mmHg
- congestive heart failure (\> NYHA I)
- Ejection fraction \<50%
- AV-Block\>I˚
- creatinine clearance \<50 mL/min
- insulin-dependent diabetes mellitus
- type 2 diabetes with microalbuminuria
- age \< 30 years
- anemia (Hb\<10 g/dl)
- malignancy chronic infection
- smoking
- serum potassium \>5.5 meq/L
- drug abuse
- potassium supplements or potassium-sparing diuretics (amiloride, spironolactone, or triamterene)
- concomitant use of strong inhibitors of CYP450 3A4 (e.g., ketoconazole, itraconazole)
- known history of Cushing disease or Morbus Addisons or diseases of the thyroid gland
Exclusion
Key Trial Info
Start Date :
July 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT00427284
Start Date
July 1 2004
Last Update
December 23 2011
Active Locations (1)
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1
University Hospital Zurich, Division of Cardiology
Zurich, Canton of Zurich, Switzerland, 8091