Status:
TERMINATED
Vaccine Therapy in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia
Lead Sponsor:
OHSU Knight Cancer Institute
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Leukemia
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
RATIONALE: Vaccines made from a peptide may help the body build an effective immune response to kill cancer cells. PURPOSE: This phase II trial is studying how well vaccine therapy works in treating ...
Detailed Description
OBJECTIVES: * Determine the antileukemic effects of tumor-specific Breakpoint Cluster Region-Abelson Murine Leukemia(BCR-ABL) junction specific peptide vaccine, as measured by a decrease in circulati...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Diagnosis of Philadelphia chromosome-positive or BCR-ABL-positive chronic phase chronic myelogenous leukemia (CML)
- In complete cytogenetic remission confirmed by 2 bone marrows ≥ 1 month apart
- Minimal residual disease
- Detectable BCR-ABL transcript levels obtained \< 6 months apart AND ≤ 0.5-log lower than the lowest value obtained within the past 6 months
- PATIENT CHARACTERISTICS:
- Karnofsky performance status 80-100%
- Bilirubin \< 2 times upper limit of normal (ULN)
- Creatinine \< 1.5 times ULN
- ALT and AST \< 2.5 times ULN
- PRIOR CONCURRENT THERAPY:
- Recovered from prior therapy
- No major surgery within the past 4 weeks
- No prior chemotherapy
- No prior immunosuppressive therapy
- No prior corticosteroids
- No prior stem cell transplantation
- No radiotherapy within the past 4 weeks
- No other concurrent investigational agents
Exclusion
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2009
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT00428077
Start Date
October 1 2005
End Date
April 1 2009
Last Update
September 2 2011
Active Locations (1)
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1
OHSU Knight Cancer Institute
Portland, Oregon, United States, 97239-3098