Status:
COMPLETED
Study of Protective Effects of Paricalcitol on Inner Layer of Vessels and Its Protective Effect on Inflammation
Lead Sponsor:
Indiana University School of Medicine
Collaborating Sponsors:
Abbott
Conditions:
Chronic Kidney Disease
Endothelial Dysfunction
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The study is about possible protective effects of paricalcitol (Zemplar) upon inflammation, blood pressure and kidney function. Kidney Inflammation occurs when white blood cells become abnormally stim...
Detailed Description
We hypothesize that use of paricalcitol in patients with chronic kidney disease will lead to improvement in oxidative stress, inflammation, endothelial function and subsequently ambulatory blood press...
Eligibility Criteria
Inclusion
- Patients with chronic kidney disease with estimated GFR of 30 mL/minute or more.
- Patients receiving stable dose of ACE inhibitor or Angiotensin receptor blockers for at least one month.
- Patients not currently hypertensive more than 180/110 mmHg by clinic blood pressure.
- Hemoglobulin A1C\< 11%
Exclusion
- Patients taking vitamin D analogs
- Calcium\> 10 mg/dL
- Phosphorus\>6 mg/dL
- Patients with anticipated need of dialysis in the next 6 weeks
- Patients unstable in the opinion of the investigator
- Patients who have emergent need for starting IV iron
- Patients who will be started on statins within the next 6 weeks
- Patients currently taking PDE5 inhibitors
- Patients allergic to radiocontrast, Zemplar or who can not take nitroglycerin
- Patients known to be HIV positive
- Patients who can not give informed consent
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2007
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00428246
Start Date
November 1 2006
End Date
July 1 2007
Last Update
June 3 2009
Active Locations (1)
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1
Richard A. Rodebush VA Medical Center
Indianapolis, Indiana, United States, 46202