Status:
COMPLETED
Trimethoprim-Sulfamethoxazole or Doxycycline for Skin and Soft Tissue Infections
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Infection
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Background: In many communities, skin and soft tissue infections (SSTI) with MRSA have become more prevalent than infections with β-lactam susceptible bacteria. This has necessitated altered empiric a...
Detailed Description
As MRSA in more likely to be isolated from a SSTI than is a β-lactam susceptible organism at Parkland Hospital in Dallas, Texas, we performed a randomized, prospective, open-label investigation in our...
Eligibility Criteria
Inclusion
- Outpatient treatment of SSTI abscesses, requiring wound packing after incision and drainage but not requiring hospitalization.
- Adults (≥ 18 years old) who were willing and able to provide informed consent.
- Able to return for follow-up at 2 to 5 days after enrollment and being accessible by telephone for follow-up assessment at 10 to 14 days and 28 to 35 days after enrollment.
Exclusion
- Exclusion criteria excluded patients with contraindications or history of hypersensitivity reaction to any of the study treatment regimens, an infected prosthesis or device, concomitant bacteremia or deep infections (e.g. osteomyelitis, necrotizing fasciitis, endocarditis), diabetic foot infections, known immunodeficiency, pregnant or breastfeeding, requirement of additional antimicrobial agents, and those who did not obtain assigned antibiotics.
Key Trial Info
Start Date :
August 1 2005
Trial Type :
INTERVENTIONAL
End Date :
July 1 2006
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00428818
Start Date
August 1 2005
End Date
July 1 2006
Last Update
January 30 2007
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