Status:
COMPLETED
Aromatic Amino Acid Metabolism in the Pathogenesis of Kwashiorkor
Lead Sponsor:
Baylor College of Medicine
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Kwashiorkor
Eligibility:
All Genders
6-18 years
Brief Summary
This research may explain whether a shortage of three special compounds called aromatic amino acids is responsible for the severe illness and high death rate of children with the kwashiorkor type of m...
Eligibility Criteria
Inclusion
- Malnourished children between 6 to 18 months of age.
- To standardize for degree of malnutrition, only patients whose weight is \< 80 % of that expected for age will be enrolled. By the Wellcome Classification (22), enrolled patients will have marasmus (\< 60 % weight/age and no edema), marasmic-kwashiorkor (\< 60 % weight/age plus edema) or kwashiorkor (\< 80 % weight/age plus edema).
- Presence of infection at admission. Infection will be defined by the presence of two or more of the following: Leukocyte count \>11,000 cells/dl, temperature at admission \> 99 oF, positive blood or urine cultures.
Exclusion
- Criteria for exclusion will include presence of cardiovascular, hepatic, renal, gastrointestinal, metabolic disease or HIV/AIDS.
Key Trial Info
Start Date :
September 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2010
Estimated Enrollment :
82 Patients enrolled
Trial Details
Trial ID
NCT00429351
Start Date
September 1 2006
End Date
June 1 2010
Last Update
February 26 2020
Active Locations (1)
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1
Tropical Metabolism Research Unit, University of the West Indies
Mona, Kingston, Jamaica, Kingston-7