Status:
COMPLETED
Sustained Release d-Amphetamine & Buprenorphine on Drug Seeking Behavior in Opioid & Cocaine Dependent Individuals
Lead Sponsor:
Wayne State University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Heroin Dependence
Opioid-Related Disorders
Eligibility:
All Genders
18-55 years
Brief Summary
The purpose of this study is to determine whether maintenance on different oral doses of sustained release d-amphetamine (SR-AMP) combined with constant-dose sublingual buprenorphine (BUP) is safe and...
Detailed Description
Heroin abusers also frequently abuse cocaine, and concurrent use of these drugs is associated with more severe drug dependence and associated psychiatric and medical problems, greater risk for HIV inf...
Eligibility Criteria
Inclusion
- Opioid dependent and Cocaine abuse or dependence, as determined by structured clinical interview for DSM-IV (SCID) and Addiction Severity Index (ASI)
- Positive urine test for opiates and cocaine
- Willing to use an adequate form of contraception for the duration of the study
- Reads and writes English
Exclusion
- Psychiatric illness, as determined by the DSM-IV criteria
- History of, or current neurological disease, including structural abnormalities, seizures, infectious disease, history of other neurological diseases or head trauma.
- History of cardiovascular disease, myocardial infarction, chest pain or palpations on exertion or drug use
- Systolic blood pressure greater than 160 or less than 95 mmHg; Diastolic blood pressure \>95 mmHg
- Clinically abnormal ECG
- Pulmonary disease, including asthma, obstructive pulmonary disease, cor pulmonale, tuberculosis
- Systemic disease (e.g., endocrinopathies, liver or kidney failure, myxedema, hypothyroidism, Addison's disease, autoimmune disease)
- Current alcohol or sedative drug dependence
- Pregnant or breastfeeding
- Currently receiving treatment for a Substance Abuse/Dependence Disorder or seeking treatment
- Been in a research study within the last 30 days
- Known phobia of injections
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2010
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00429767
Start Date
January 1 2007
End Date
January 1 2010
Last Update
June 5 2012
Active Locations (1)
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1
Wayne State University
Detroit, Michigan, United States, 48207