Status:
COMPLETED
Neurovascular Coupling in Eyes of Glaucoma Patients
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Glaucoma
Ocular Hypertension
Eligibility:
All Genders
40-79 years
Brief Summary
We hypothesize that glaucoma patients demonstrate an impaired retinal vascular response to the flicker stimulus, and that this disturbance is predictive of the progression of glaucomatous damage. The...
Detailed Description
Rationale: The term neurovascular coupling refers to the vascular response to an increased neuronal activity. The contact of the nerve terminals to the cortical blood vessels is mostly realized throug...
Eligibility Criteria
Inclusion
- Glaucoma
- Ocular hypertension
Exclusion
- PEX or pigment dispersion syndrome
- A history of an acute glaucoma attack
- Chamber angle dysgenesia
- Any form of secondary glaucoma
- Diabetes
- High levels of blood lipids
- Systemic or ocular circulatory diseases
- Medication, drugs, alcohol, smoking
- Systolic blood pressure above 145 mmHg or a diastolic above 95 mmHg
- Visual acuity worse than 20/25
- High ametropia (spherical equivalent \< -5 diopters or \> +3 diopters)
- Astigmatism above 2 diopters
- Significant cataract filtering procedures
Key Trial Info
Start Date :
December 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00429819
Start Date
December 1 2006
End Date
December 1 2014
Last Update
December 16 2014
Active Locations (1)
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1
University Eye Clinic
Basel, Canton of Basel-City, Switzerland, 4031