Status:
UNKNOWN
Double Blind Crossover Comparison of Diuretics in the Young
Lead Sponsor:
University of Cambridge
Collaborating Sponsors:
British Heart Foundation
Conditions:
Low-Renin Hypertension
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
The principle objective of the study is to determine whether low-renin (i.e. salt sensitive) hypertension at a young age is caused by the kidneys hanging onto too much salt as a result of an over acti...
Detailed Description
Studies suggest that patients with low renin hypertension respond better to diuretics than other hypertensive drug groups. The aim of the study is to rotate patients through the four main diuretic gro...
Eligibility Criteria
Inclusion
- Aged 18-45
- male or female
- Hypertensive - 3 clinic SBP \>=140mmHg; or 3 clinic DBP \>=90mmHg; or ABPM or home BP \>=130(SBP) or 85(DBP)
- 24hr Na+\<160mmol/l
- EITHER {Plasma renin\<=10mU/L (measured untreated, or whilst receiving only CCB+/-diuretic} + {Plasma renin \<=40mU/L (measured on an ACEi or ARB, which approximately double s the plasma renin)} OR Plasma renin \<5mU/L (measured untreated, or receiving any antihypertensive drug other than a beta-blocker
Exclusion
- Documented history of gout
- Abnormal renal function (both elevated serum creatinine and reduced creatinine clearance
- SBP \> 170mmHg or Diastolic \>110mmHg despite treatment with permitted background treatment
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
End Date :
July 1 2007
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00429897
Start Date
August 1 2006
End Date
July 1 2007
Last Update
February 1 2007
Active Locations (1)
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1
University of Cambridge - Addenbrookes Hospital
Cambridge, United Kingdom, CB2 2QQ