Status:
TERMINATED
Ceftriaxone Vs Levofloxacin on Cytokine Expression in Pneumococcal Pneumonia
Lead Sponsor:
Hospital Mutua de Terrassa
Collaborating Sponsors:
Fondo de Investigacion Sanitaria
Conditions:
Pneumonia, Pneumococcal
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare levofloxacin vs ceftriaxone impact on the cytokine production in patients with pneumococcal pneumonia.
Detailed Description
Bacterial alveolar invasion is followed by a compartmentalized inflammatory response. Data suggest that some antimicrobials may induce a differential release of cytokines, with the potential of either...
Eligibility Criteria
Inclusion
- patients with an acute febrile respiratory illness accompanied by a new radiographic infiltrate consistent with this diagnosis.
- and with a confirmed pneumococcal aetiology
Exclusion
- age \< 18 years,
- pneumonia distal to endobronchial obstruction,
- pulmonary tuberculosis,
- bronchiectasis,
- known allergy to B-lactams or fluoroquinolones,
- underlying systemic autoimmune disease
- immunocompromised states including patients on maintenance oral corticosteroids, HIV infection,
- pregnancy,
- patients that received antimicrobial therapy in the 15 days preceding the current episode and those who had received fluoroquinolones in the last month, or non steroidal anti-inflammatory therapy in the last two weeks.
- Patients with renal failure (serum creatinine \> 2 mg / dL),
- and patients with a documented pneumococcal pneumonia in the previous 4 weeks
Key Trial Info
Start Date :
August 1 2004
Trial Type :
INTERVENTIONAL
End Date :
September 1 2005
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00429975
Start Date
August 1 2004
End Date
September 1 2005
Last Update
February 1 2007
Active Locations (1)
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1
Hospital Mutua de Terrassa
Terrassa, BARCELONA, Spain, 08221