Status:
COMPLETED
Neurovascular Coupling in Eyes of Glaucoma Patients
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Glaucoma
Ocular Hypertension
Eligibility:
All Genders
40-79 years
Brief Summary
We hypothesize that glaucoma patients demonstrate an impaired retinal vascular response to the flicker stimulus, and that this disturbance is predictive of the progression of glaucomatous damage. The...
Detailed Description
Rationale: The term neurovascular coupling refers to the vascular response to an increased neuronal activity. The contact of the nerve terminals to the cortical blood vessels is mostly realized throug...
Eligibility Criteria
Inclusion
- glaucoma
- ocular hypertension
Exclusion
- highest ever measured intraocular pressure (IOP) equal or higher than 30 mmHg
- peripapillary hemorrhage
- any suspicion of progression
- PEX (pseudo exfoliations syndrome) or pigment dispersion syndrome
- a history of an acute glaucoma attack
- chamber angle dysgenesia
- any form of secondary glaucoma
- diabetes
- high levels of blood lipids
- systemic or ocular circulatory diseases
- medication, drugs, alcohol, smoking
- systolic blood pressure above 145mmHg or a diastolic above 95mmHg
- visual acuity worse than 20/25
- high ametropia (spherical equivalent \< -5 diopters or \> +3 diopters)
- astigmatism above 2 diopters
- significant cataract
- filtering procedures
Key Trial Info
Start Date :
December 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00430209
Start Date
December 1 2006
End Date
December 1 2013
Last Update
December 11 2013
Active Locations (1)
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1
University Eye Clinic
Basel, Canton of Basel-City, Switzerland, 4031