Status:
COMPLETED
Photographic Imaging of the Retina and Optic Nerve Head of Glaucoma Patients and Normal Controls
Lead Sponsor:
Selim Orguel
Conditions:
Glaucoma
Eligibility:
All Genders
45-80 years
Brief Summary
Retinal structures are difficult to visualize because the retina is optically transparent. In glaucoma, the microglia in the retina becomes activated in eyes with glaucomatous damage. The microglia fo...
Detailed Description
Glaucoma is an optic neuropathy characterized by a progressive loss of retinal ganglion cells and cupping of the optic nerve head associated with visual function defects. Increased intraocular pressur...
Eligibility Criteria
Inclusion
- For NTG patients :
- untreated intraocular pressure equal to or less than 21mmHg or
- median intraocular pressure equal to or less than 20mmHg
- For HTG patients:
- mean untreated intraocular pressure more than 21mmHg
- For both:
- open drainage angles on gonioscopy
- typical optic disc damage with glaucomatous cupping and thinning of neuroretinal rim
- absence of any secondary cause for a glaucomatous optic neuropathy
- visual field defects congruent to glaucomatous disc damage (disc/field correlation)
- Healthy subjects:
- no history of ocular diseases
- no current topical medication
- no drug or alcohol abuse
- best corrected visual acuity above 20/25 in both eyes
- no pathological findings upon a slit-lamp examination and fundoscopy
- IOP \< 21 mmHg in both eyes
Exclusion
- For NTG and HTG patients:
- any other form of retinal or neuroophthalmological disease that could cause gliosis-like retinal alterations or result in visual field defects
- history of chronic or recurrent severe inflammatory eye disease
- history of ocular trauma or intraocular surgery
- history of infection or inflammation within the past 3 months
- history and clinical evidence for other retinal disease
Key Trial Info
Start Date :
January 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2017
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00430274
Start Date
January 1 2006
End Date
April 1 2017
Last Update
August 25 2017
Active Locations (1)
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1
University Eye Clinic
Basel, Switzerland, 4031