Status:
COMPLETED
Acoustic Startle Reduction In Cocaine Dependence
Lead Sponsor:
Emory University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine-Related Disorders
Eligibility:
All Genders
18-80 years
Brief Summary
Chronic cocaine administration leads to changes in brain function that persist long after the acute withdrawal phase. The acoustic startle response (ASR) is a well characterized reflexive response to ...
Eligibility Criteria
Inclusion
- Cocaine dependent subjects:
- males or females,
- age 18-80,
- with a DSM-IV diagnosis of cocaine dependence,
- a usage history characterized by a minimum of 1 year of at least $50 per day or weekly binges of at least $200 of cocaine use.
Exclusion
- current clinically significant medical illness (including HIV, because of possible confound of neurological involvement),
- current or past neurological illness, and no history of head trauma with loss of consciousness ≥ 5 minutes because of the possible confound of neurological damage to startle-modulating brain areas,
- other Axis I psychiatric disorder currently or in the previous three months with the exception of substance induced disorders as determined by SCID,
- history of schizophrenia, schizoaffective disorder, posttraumatic stress disorder, or bipolar disorder,
- known hearing impairments (intact hearing will be insured by brief audiology screening),
- dependence on other drugs or alcohol within the previous 6 months, as confirmed by ASI.
- Healthy controls:
- males or females,
- age 18-80.
- Exclusion criteria:
- history of any Axis I psychiatric illness or history of treatment as determined by SCID Axis I,
- substance dependence or abuse history by ASI and SCID,
- no current clinically significant medical illness (including HIV),
- current or past neurological illness, or history of head trauma with loss of consciousness ≥ 5 minutes because of the possible confound of neurological damage to startle-modulating brain areas,
- known hearing impairments (intact hearing will be insured by brief audiology screening),
- Axis I disorder, including substance dependence, in first degree family member.
- Family members of cocaine subjects:
- males or females,
- age 18-80,
- family member of cocaine-dependent subject enrolled in study.
- Exclusion criteria:
- history of any Axis I psychiatric illness or history of treatment as determined by SCID Axis I,
- substance dependence history by ASI and SCID, or substance abuse within the prior 5 years,
- no current clinically significant medical illness (including HIV),
- current or past neurological illness, or history of head trauma with loss of consciousness,
- known hearing impairments
Key Trial Info
Start Date :
September 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 19 2011
Estimated Enrollment :
144 Patients enrolled
Trial Details
Trial ID
NCT00430690
Start Date
September 1 2006
End Date
July 19 2011
Last Update
August 7 2019
Active Locations (1)
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1
Atlanta Veterans Adminstration Medical Center
Decatur, Georgia, United States, 30033