Status:
COMPLETED
Sequence Effect in Parkinson's Disease
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Parkinson's Disease
Eligibility:
All Genders
18+ years
Brief Summary
This study will explore sequence effect, a fatigue or tiredness commonly seen in patients with Parkinson's disease after they have been doing the same thing for a while. The study will use a new devic...
Detailed Description
Objective: The long-term goal is to provide new insight into the effect of long-lasting sequence movements (sequence effect) by investigating de novo and advanced Parkinson's disease (PD) patients wi...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age 18 years and older.
- Right hand dominant (Edinburgh Handedness Quotient greater than 60).
- Able to provide consent for the protocol.
- Hoehn \& Yahr stages: I - III (de novo PD patients); II - IV (advanced PD patients).
- Never treated with antiparkinsonian medications (de novo PD patients).
- Able to go off of antiparkinsonian medications for a minimum 14 hours (advanced PD patients), i.e. overnight withdrawal until after the experiments are completed here at NIH.
- EXCLUSION CRITERIA:
- Patients with any other medical, surgical, neurological or psychiatric conditions except PD.
- Patients with known symptomatic wearing off.
- Pregnant women.
- Concurrent use of tricyclic antidepressants, neuroleptic agents, or any other licit or illicit drugs other than antiparkinsonian agents that could lower the seizure threshold.
- Persons with surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), intracardiac lines that may pose a physical hazard during magnetic stimulation will also be excluded.
- Patients with history of seizure disorder or epilepsy.
- Subjects without the capacity to give informed consent.
- If participation in the study would, in the opinion of the investigators, cause undue risk or stress for reasons such as excessive fatigue, general frailty, or excessive apprehension.
Exclusion
Key Trial Info
Start Date :
February 1 2007
Trial Type :
OBSERVATIONAL
End Date :
December 24 2008
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00431366
Start Date
February 1 2007
End Date
December 24 2008
Last Update
July 2 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892