Status:
COMPLETED
Effect of Elevated Plasma-Free-Fatty-Acids on Renal Hemodynamic Parameters
Lead Sponsor:
Medical University of Vienna
Conditions:
Renal Circulation
Renal Plasma Flow
Eligibility:
MALE
19-35 years
Phase:
NA
Brief Summary
Type 2 diabetes is frequently associated with elevation of plasma-free fatty acids (FFA). Studies indicate that elevation of plasma-FFA induces insulin resistance and also causes endothelial dysfuncti...
Eligibility Criteria
Inclusion
- Men aged between 19 and 35 years
- Body mass index between 15th and 85th percentile (Must et al. 1991)
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
- Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant
Exclusion
- Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
- Evidence of hypertension, pathologic hyperglycemia, hyperlipidemia
- Treatment in the previous 3 weeks with any drug
- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with distribution, metabolism or excretion of study drugs
- History of hypersensitivity to the trial drug or to drugs with a similar chemical structure
Key Trial Info
Start Date :
July 1 1999
Trial Type :
INTERVENTIONAL
End Date :
June 1 2000
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT00431665
Start Date
July 1 1999
End Date
June 1 2000
Last Update
February 6 2007
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Austria, 1090