Status:
COMPLETED
Effect of Bosentan on Exercise Capacity at High Altitude
Lead Sponsor:
VA Loma Linda Health Care System
Collaborating Sponsors:
Actelion
Conditions:
Altitude
Pulmonary Hypertension
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
Brief Summary
This study is to determine whether bosentan will alter exercise capacity after rapid ascent to high altitude. We hypothesize that bosentan administration will improve arterial oxygenation and exercis...
Detailed Description
Both the prostacyclin and the nitric oxide pathways are important in modulating hypoxic pulmonary vasoconstriction (HPV). There is little information about the role of the endothelin pathway at high a...
Eligibility Criteria
Inclusion
- Normal healthy subjects aged 18 - 55 years
Exclusion
- Pregnancy
- Heart, lung or liver disease
- Use of glyburide, cyclosporin A
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
End Date :
February 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00432978
Start Date
July 1 2006
End Date
February 1 2007
Last Update
April 18 2007
Active Locations (1)
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1
VA Loma Linda Healthcare System
Loma Linda, California, United States, 92357