Status:
COMPLETED
Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma
Lead Sponsor:
Christine Mauz-Körholz
Collaborating Sponsors:
Deutsche Krebshilfe e.V., Bonn (Germany)
Euronet Worldwide
Conditions:
Lymphoma
Eligibility:
All Genders
Up to 17 years
Phase:
PHASE3
Brief Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination c...
Detailed Description
OBJECTIVES: Primary * Determine whether the 5-year event-free survival (EFS) rate in pediatric patients with Hodgkin's lymphoma with an adequate response after 2 courses of vincristine, etoposide, p...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed classical Hodgkin's lymphoma
- No lymphocyte-predominant Hodgkin's lymphoma
- Fine-needle biopsy not sufficient
- No prior treatment for Hodgkin's lymphoma except for recommended pre-phase therapy for a large mediastinal tumor
- PATIENT CHARACTERISTICS:
- No known hypersensitivity or contraindication to study drugs
- No other current malignancy
- No severe concurrent disease (e.g., immune deficiency syndrome)
- Not pregnant or nursing
- Fertile patients must use effective contraception during and for up to 1 year after completion of study treatment
- No known HIV positivity
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No prior chemotherapy or radiotherapy
- At least 30 days since prior and no other concurrent investigational drugs or participation in another investigational trial
Exclusion
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
2134 Patients enrolled
Trial Details
Trial ID
NCT00433459
Start Date
January 1 2007
End Date
January 1 2013
Last Update
March 26 2020
Active Locations (2)
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1
Universitaetsklinikum Giessen-Marburg
Giessen, Germany, D-35385
2
Royal Hospital for Sick Children
Edinburgh, Scotland, United Kingdom, EH9 1LF