Status:

UNKNOWN

Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis

Lead Sponsor:

University of Oxford

Collaborating Sponsors:

Wellcome Trust

Conditions:

HIV Infections

Tuberculous Meningitis

Eligibility:

All Genders

15+ years

Phase:

NA

Brief Summary

The optimal time to initiate antiretroviral therapy (ART) in HIV-associated tuberculous meningitis (TBM) unknown. There are concerns that immediate ART may worsen rather than improve outcome, because ...

Detailed Description

Title: Study of immediate versus deferred antiretroviral therapy in HIV-associated tuberculous meningitis Study design: A randomized, double blind, placebo-controlled trial with 2 parallel arms Sample...

Eligibility Criteria

Inclusion

  • age 15 years or older
  • HIV antibody positive
  • clinical diagnosis of TB meningitis

Exclusion

  • positive CSF Gram or India ink stain
  • known or suspected pregnancy
  • antituberculous treatment 8 - 30 days immediately prior to recruitment
  • previous antiretroviral therapy
  • laboratory contraindications to antiretroviral or antituberculous therapy
  • lack of consent.

Key Trial Info

Start Date :

September 1 2005

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

December 1 2008

Estimated Enrollment :

253 Patients enrolled

Trial Details

Trial ID

NCT00433719

Start Date

September 1 2005

End Date

December 1 2008

Last Update

August 7 2008

Active Locations (2)

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Page 1 of 1 (2 locations)

1

Hospital for Tropical Diseases

Ho Chi Minh City, Vietnam

2

Pham Ngoc Thach Hospital

Ho Chi Minh City, Vietnam