Status:
COMPLETED
Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans
Lead Sponsor:
University of Washington
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Healthy
Eligibility:
All Genders
18-49 years
Phase:
NA
Brief Summary
Objectives: This proposal addresses the overall hypothesis that ambient fine particulate matter exerts cardiovascular health effects via alteration of endothelial homeostasis, through a mechanism medi...
Detailed Description
OBJECTIVES Evidence of the cardiovascular health effects of both acute and chronic exposure to ambient fine particulate matter (PM) has continued to accumulate in epidemiologic and experimental studie...
Eligibility Criteria
Inclusion
- Healthy adults aged 18-49.
Exclusion
- Nonsmokers, no history of hypertension, asthma, diabetes, hypercholesterolemia, or other chronic conditions requiring ongoing medical care. No recent history of antioxidant, vitamin/mineral/botanical, or fatty acid supplementation beyond a daily multi-vitamin.
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2010
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00434005
Start Date
July 1 2008
End Date
August 1 2010
Last Update
January 16 2013
Active Locations (1)
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1
Northlake Laboratory
Seattle, Washington, United States, 98105