Status:
COMPLETED
Does DHEA Enhance the Effects of Exercise in Postmenopausal Women?
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
National Institute on Aging (NIA)
National Institutes of Health (NIH)
Conditions:
Aging
Eligibility:
FEMALE
55-75 years
Phase:
NA
Brief Summary
Dehydroepiandrostrone (DHEA) and its sulfated ester (DHEAS) are high circulating weak androgens which have been associated with conditions that accompany age-related decline such as sarcopenia, hyperi...
Eligibility Criteria
Inclusion
- Subjects will be postmenopausal women between the ages of 60 and 75 years old.
- Women with levels of DHEA less than 110 mg will be selected.
Exclusion
- Individuals with history or biochemical evidence of liver disease, cardiovascular disease (other than controlled hypertension); polycythemia, cerebrovascular disorders, or disorder of glucose metabolism with fasting hyperglycemia or hypoglycemia will be excluded.
- Use of psycotropic drugs within six months prior to enrollment
- History of severe depression or psychotic disorder
- Professional athletes or BMI greater than 30kg/m2
- Anyone who has been in a regular (greater than twice/weekly) exercise program for more than 2 months prior to the study
- Severe rheumatologic condition with chronic pain not well controlled.
- Use of DHEA, estrogen, progesterone, testosterone, corticosteroid products up to six months prior to study
Key Trial Info
Start Date :
April 1 2003
Trial Type :
INTERVENTIONAL
End Date :
April 1 2007
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00434915
Start Date
April 1 2003
End Date
April 1 2007
Last Update
March 23 2011
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905