Status:
COMPLETED
Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence
Lead Sponsor:
Finnish Institute for Health and Welfare
Conditions:
Alcohol Dependence
Eligibility:
All Genders
25-65 years
Phase:
PHASE4
Brief Summary
The aim of this study was to compare the effect of manual based cognitive therapy in adjunct of three different pharmacotherapy.
Detailed Description
Context Alcoholism is common clinical problem and its treatment has no standard and is controversy. Different pharmacotherapy's, acamporsate, nalterxone and disulfiram have shown to improve the drinki...
Eligibility Criteria
Inclusion
- Alcohol dependence (ICD-10)
Exclusion
- Clinically significant symptoms of alcohol withdrawal
- Significant recently diagnosed psychiatric disease (psychosis, personality disorder or suicidal tendency that appeared during the initial interview)
- Current psychiatric disease demanding special treatment or medication including DSM-IV determined drug dependence other than alcohol or nicotine dependence
- Current use of any opioids within four weeks before screening
- Significant brain, thyroid, kidney, uncompensated heart disease, or clinically significant liver disease (cirrhosis, aqlcoholic hepatitis or ALAT \> 200)
- Pregnancy, nursing, or women refused to use a reliable method for birth control
Key Trial Info
Start Date :
September 1 2000
Trial Type :
INTERVENTIONAL
End Date :
April 1 2005
Estimated Enrollment :
243 Patients enrolled
Trial Details
Trial ID
NCT00435435
Start Date
September 1 2000
End Date
April 1 2005
Last Update
February 16 2007
Active Locations (1)
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1
National Public Health Institute, Department of Mental Health and Alcohol Research
Helsinki, Finland, 00251