Status:
COMPLETED
Controlled Exposures to Air Pollution in Patients With Coronary Heart Disease
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
Umeå University
Conditions:
Coronary Heart Disease
Eligibility:
All Genders
18-70 years
Phase:
EARLY_PHASE1
Brief Summary
Air pollution is a major cause of cardiovascular morbidity and mortality. The components of air pollution responsible and the mechanisms through which they might mediate these harmful effects remain o...
Detailed Description
Observational studies suggest that exposure to air pollution may worsen symptoms of angina and trigger acute myocardial infarction. These findings are limited by imprecision in the measurement of poll...
Eligibility Criteria
Inclusion
- Previous myocardial infarction (\>6 months previously) treated by primary angioplasty and stenting
- On standard secondary preventative therapy
Exclusion
- Angina pectoris (Canadian Cardiovascular Society grade ≥2)
- History of arrhythmia
- Diabetes mellitus
- Uncontrolled hypertension
- Renal or hepatic failure
- Unstable coronary disease (acute coronary syndrome or unstable symptoms within 3 months)
- Occupational exposure to air pollution
- Current smokers
- Asthma
- Inter-current illness
Key Trial Info
Start Date :
April 1 2006
Trial Type :
INTERVENTIONAL
End Date :
June 1 2006
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00437138
Start Date
April 1 2006
End Date
June 1 2006
Last Update
February 19 2007
Active Locations (1)
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1
Umeå University
Umeå, Västerbotten County, Sweden, 901 85