Status:
COMPLETED
SNIFF 120: Study of Nasal Insulin to Fight Forgetfulness (120 Days)
Lead Sponsor:
University of Washington
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Mild Cognitive Impairment
Alzheimer's Disease
Eligibility:
All Genders
55+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to find out if insulin, when administered as a "nasal spray" into the nasal passages, improves memory in adults with mild cognitive impairment (MCI) or Alzheimer's disease...
Detailed Description
A growing body of evidence suggests that insulin plays a role in normal memory processes and that insulin abnormalities may contribute to cognitive and brain changes associated with Alzheimer's diseas...
Eligibility Criteria
Inclusion
- Age 55 or greater
- Good physical health
- Memory impairment with a diagnosis of mild cognitive impairment (MCI) or Alzheimer's disease (AD)
- Participants on stable doses of Memantine (Namenda) or cholinesterase inhibitors will be eligible
Exclusion
- Chronic sinus problems/allergies with chronic use of nasal decongestants or antihistamines
- Significant neurologic disease that might affect cognition (other than AD), such as stroke, Parkinson's disease, multiple sclerosis, severe head injury with loss of consciousness for more than 30 minutes or with permanent neurologic symptoms
- Significant medical illness or organ failure, such as uncontrolled hypertension or cardiovascular disease, chronic obstructive pulmonary disease, liver disease, or kidney disease
- Preexisting diabetes or current or previous use of hypoglycemic agents or insulin; participants will be excluded if they have a fasting blood sugar greater than 165 on baseline OGTT
- Clinically significant elevations in liver function tests, cholesterol, or triglycerides
- Major psychiatric disorders (e.g., untreated major depression and schizophrenia)
- Chronic use of the following types of medications: anti-psychotic, anxiolytic, and opiates
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
173 Patients enrolled
Trial Details
Trial ID
NCT00438568
Start Date
June 1 2006
End Date
December 1 2011
Last Update
September 14 2012
Active Locations (1)
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1
Veterans Administration Puget Sound Health Care System
Seattle, Washington, United States, 98108