Status:
COMPLETED
Ketamine Versus Etomidate During Rapid Sequence Intubation: Consequences on Hospital Morbidity
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Intubation; Difficult
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The expected benefit is a reduction of the morbidity of patients admitted in the intensive care unit having received ketamine for intubation.
Detailed Description
The national recommendations of sedation concerning the intubation in emergency settings advise the use of a hypnotic, etomidate associated to succinylcholine. A national inquiry showed that more than...
Eligibility Criteria
Inclusion
- Patient requiring sedation for prehospital endotracheal intubation
- Age ≥ 18 years
- Consent of a family member if present, then of the patient for the pursuit of research
Exclusion
- Patient in cardiac arrest
- Presence of contraindication to succinylcholine:
- Personal or familial history of malignant hyperthermia
- Known hypersensitivity to succinylcholine
- Skeletal muscle disease
- Myasthenia
- Known hyperkalemia
- Severe ophthalmic injury
- Known congenital deficit in plasmatic pseudo-cholinesterase
- Presence of contraindication to ketamine:
- Known hypersensitivity to ketamine
- Known porphyria
- Severe hypertension
- Presence of contraindication to etomidate:
- Known untreated adrenal insufficiency
- Known hypersensitivity to etomidate
- Known pregnancy
- Unaffiliated patient to the social insurance
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2008
Estimated Enrollment :
655 Patients enrolled
Trial Details
Trial ID
NCT00440102
Start Date
April 1 2007
End Date
March 1 2008
Last Update
September 22 2011
Active Locations (1)
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1
Chu Avicenne
Bobigny, France, 93000