Status:
COMPLETED
Effects of N-acetylcysteine on Muscle Fatigue in Hemodialysis
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
End-Stage Renal Disease
Dialysis
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purposes of the study are to determine whether oxidative stress causes the muscle of dialysis patients to tire more quickly than muscle of people without kidney disease and to determine whether tr...
Detailed Description
Muscle dysfunction is a major problem for patients with end-stage renal disease (ESRD). Specifically, these patients experience approximately three-fold greater muscle fatigue of the lower extremities...
Eligibility Criteria
Inclusion
- age greater than 18 years
- undergoing hemodialysis for 3 months or more or healthy control without kidney disease
Exclusion
- inability to give informed consent
- diagnosis of diabetes mellitus
- musculoskeletal contraindication to exercise
- infection requiring intravenous antibiotics within 2 months
- hospitalization within 2 months
- ingestion of antioxidant supplements within one month
- requirement for systemic anticoagulation
- estimated GFR \<60 ml/min/1.73 m2 for healthy controls
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00440869
Start Date
March 1 2007
End Date
December 1 2009
Last Update
March 3 2010
Active Locations (1)
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1
San Francisco VA Medical Center
San Francisco, California, United States, 94121