Status:
WITHDRAWN
Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise
Lead Sponsor:
Radboud University Medical Center
Conditions:
Cardiovascular Disease
Ischemia-reperfusion Injury
Eligibility:
MALE
18-50 years
Phase:
NA
Brief Summary
To adjust our forearm model for ischemia reperfusion injury, in order to used it for assessment of ischemia reperfusion damage in elderly and patients. To test the effect of ischemic postconditioning...
Detailed Description
Recently, ischemic postconditioning has been identified as a protective intervention against ischemia-reperfusion injury. In animal studies, the signalling pathway of this (impressive) protective phen...
Eligibility Criteria
Inclusion
- Age 18-50 years
- No physical limitation to perform ischemic exercise
- Informed consent
Exclusion
- Diabetes (fasting glucose \> 7,0mmol/l, or random glucose \>11,0mmol/l)
- hyperlipidemia (random total cholesterol \> 6.5 mmol/l)
- Hypertension (supine SBP/DBP \> 140/90 mmHg at screening)
- Any cardiovascular disease
- Drug abuse
- Concomitant chronic use of medication
- Administration of radioactivity in research setting during the last 5 years
- Participation to any drug-investigation during the previous month as checked with VIP check according to CRCN standard procedures.
Key Trial Info
Start Date :
October 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2007
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00441714
Start Date
October 1 2007
End Date
December 1 2007
Last Update
November 10 2015
Active Locations (1)
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1
Radboud University Nijmegen Medical Centre
Nijmegen, Netherlands, 6500HB