Status:
TERMINATED
Transfusion-Associated Microchimerism in Previously Injured Individuals Who Received a Blood Transfusion
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Chimerism
Blood Transfusion
Eligibility:
All Genders
8+ years
Brief Summary
Blood transfusions are frequently necessary in situations in which there is a large amount of blood loss. In some individuals who receive a blood transfusion, white blood cells from the donor's blood ...
Detailed Description
Approximately 10% to 15% of injured patients who receive blood transfusions experience a condition known as transfusion-associated microchimerism. This occurs when white blood cells, or leukocytes, fr...
Eligibility Criteria
Inclusion
- Hospitalized for traumatic injury, thermal injury, or an elective orthopedic surgical procedure from 2000 to 2003 at the University of California at Davis Medical Center
- Received at least 1 unit of transfused red blood cells
Exclusion
- Currently incarcerated
- Inadequate decision-making capacity of the participant and no available surrogate decision-maker
- Prior bone marrow or solid organ transplantation
- Prior blood transfusion other than at the time of hospitalization
- Any history of an autoimmune disorder prior to hospitalization
Key Trial Info
Start Date :
August 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
59 Patients enrolled
Trial Details
Trial ID
NCT00441779
Start Date
August 1 2008
End Date
October 1 2011
Last Update
July 12 2016
Active Locations (1)
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1
University of California, Davis, Medical Center
Sacramento, California, United States, 95817