Status:
COMPLETED
The Effect of Etomidate on Patient Outcomes After Single Bolus Doses
Lead Sponsor:
Advocate Hospital System
Collaborating Sponsors:
Emergency Medicine Foundation
Conditions:
Sepsis
Trauma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The primary aim is to determine the difference in hospital length of stay between septic patients given etomidate and those given midazolam for induction during rapid sequence intubation (RSI) in the ...
Detailed Description
Rationale: Although the use of the drug etomidate for continuous sedation in mechanically ventilated patients was found to have detrimental effects on patient mortality shortly after its introduction ...
Eligibility Criteria
Inclusion
- All critically ill adult patients who present to the emergency department in need of ventilatory support and having a traumatic or suspected infectious etiology for their illness. Specifically, all patients meeting criteria for severe sepsis, septic shock, or the sepsis syndrome by fulfillment of two of the four criteria for the systemic inflammatory response syndrome (temperature greater than 38.3°C or less than 36°C, heart rate greater than 90, respiratory rate greater than 20 or PaCO2 less than 32, white blood cell count greater than 12,000 or less than 4000 or greater than 10% bands).
- All patients presenting in respiratory distress from a presumed pulmonary source of infection and requiring ventilatory support.
- All patients presenting after any traumatic injury and requiring ventilatory support.
Exclusion
- An age less than 18
- Pregnancy
- Do-not-resuscitate status
Key Trial Info
Start Date :
October 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
122 Patients enrolled
Trial Details
Trial ID
NCT00441792
Start Date
October 1 2007
End Date
December 1 2010
Last Update
April 11 2012
Active Locations (1)
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1
Advocate Christ Medical Center
Oak Lawn, Illinois, United States, 60453