Status:
COMPLETED
Uremic Pruritus, Cytokines and Polymethylmethacrylate Artificial Kidney
Lead Sponsor:
China Medical University Hospital
Conditions:
Uremia
Pruritus
Eligibility:
All Genders
26-82 years
Phase:
PHASE4
Brief Summary
Background: Uremic pruritus is one of the common complications in long-term dialysis patients. In general, many factors including xerosis, elevated serum calcium, phosphate, calcium-phosphate product,...
Eligibility Criteria
Inclusion
- Patients with chronic pruritus (\>3 months) were screened using traditional visual analogue scale (VAS) and then scored using a pruritus questionnaire (pruritus scoring system).
- Other inclusion criteria were that patients enrolled should be dialysed for 4 hours, three times a week, with KT/V \>1.2, serum albumin\> 3.0 mg/dl, hematocrit \> 24%, ferritin \< 900 ng/ml, phosphate \<7 mg/dl, corrected calcium \<11 mg/dl, calcium-phosphate product \< 70, intact parathyroid hormone (iPTH) \<600 pg/ml, and normal serum level of alanine aminotransferase and bilirubin in past 3 months.
Exclusion
- Pruritus unrelated to renal failure
- Evidence of malignancy
- Liver cirrhosis diagnosed by echogram or admission within 3 months of the start of the study.
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
End Date :
September 1 2006
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00442819
Start Date
July 1 2006
End Date
September 1 2006
Last Update
March 2 2007
Active Locations (1)
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1
China Medical University Hospital
Taichung, Taiwan, 404