Status:
TERMINATED
Effect of Acid Reflux on Respiratory Physiology During Exercise in Athletes With GER-Response to Acid Suppression
Lead Sponsor:
University of Utah
Collaborating Sponsors:
AstraZeneca
Conditions:
Exercise Triggered Asthma
Gastroesophageal Reflux
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
We propose that acid reflux affects respiratory dynamics (breathing) in patients who are exercising and that athletes improve their exercise capacity with acid suppression therapy. It is our intent to...
Detailed Description
This is a randomized, blinded, cross-over trial. We plan to take athletes with classical GER, cough, shortness of breath, chest tightness during exercise and subject them to complete pulmonary functio...
Eligibility Criteria
Inclusion
- We plan to take athletes (cyclists) with GER (heartburn symptoms on a daily-weekly basis which are either improved by a trial of acid suppression or objectively documented via pH/endoscopic testing- this may include during exercise) who experience one or more of the following symptoms during exercise, limiting their perceived ability to exercise to full capacity:
- choking
- cough
- wheezing
- shortness of breath
- chest tightness during exercise
- Athletes will be defined as persons who exercise on a routine basis (at least 3 times a week on average) for at least the past 6 months.
- Subjects must be at least 18 years old.
Exclusion
- Pregnancy
- Age less than 18 years or greater than 65 years
- Abnormal methacholine challenge tests will not exclude one from enrollment as (has been documented in a prior study) often patients with GER will have heightened bronchial reactivity.
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT00444236
Start Date
April 1 2007
End Date
September 1 2009
Last Update
January 21 2016
Active Locations (1)
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1
University of Utah Health Sciences Center
Salt Lake City, Utah, United States, 84132