Status:
COMPLETED
Genetic Analysis for Predicting of Relapse During Steroid Treatment for Autoimmune Pancreatitis (AIP)
Lead Sponsor:
Asan Medical Center
Conditions:
Pancreatitis
Eligibility:
All Genders
19-75 years
Brief Summary
To determine whether certain alleles or haplotypes of major histocompatibility complex gene are associated with AIP in Korean population, we undertook this study with high-resolution typing for HLA (s...
Detailed Description
Autoimmune chronic pancreatitis (AIP) can be defined as a chronic inflammation of the pancreas due to an autoimmune mechanism; autoimmunity is responsible for producing the pancreatic lesion. AIP is a...
Eligibility Criteria
Inclusion
- Patient with autoimmune pancreatitis
- The diagnosis is mainly based on the following three characteristic findings proposed by Japan Pancreas Society in 2002: (1)Imaging studies: irregular narrowing of the main pancreatic duct and diffuse enlargement of the pancreas, (2) Laboratory data: elevated serum IgG or the presence of autoantibodies, (3) Histological examinations: fibrotic changes with lymphoplasmacytic infiltration in the pancreatic tissue.
- Age 18 years and above
- No serious medical or psychological condition that would preclude study treatment
- Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures
Exclusion
- Age below 18 years
- Pregnancy
- Active alcohol or drug abuse
- Unstable or unwilling to comply with follow up
Key Trial Info
Start Date :
February 1 2002
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00444444
Start Date
February 1 2002
End Date
June 1 2007
Last Update
June 26 2007
Active Locations (1)
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1
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center
Seoul, South Korea, 138-736