Status:
COMPLETED
Bevacizumab and Doxorubicin Hydrochloride Liposome in Treating Women With Locally Recurrent or Metastatic Breast Cancer
Lead Sponsor:
Swiss Cancer Institute
Conditions:
Breast Cancer
Eligibility:
FEMALE
18+ years
Phase:
PHASE2
Brief Summary
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or...
Detailed Description
OBJECTIVES: Primary * Determine the safety and tolerability of bevacizumab and doxorubicin hydrochloride liposome in women with locally recurrent or metastatic breast cancer. Secondary * Determine...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Cytologically or histologically confirmed breast cancer
- Metastatic OR locally recurrent disease
- Unresectable disease
- Not amenable to radiotherapy
- Measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 20 mm by conventional techniques OR ≥ 10 mm by spiral CT scan
- Measurable disease must be outside irradiated areas
- ErbB2-negative disease by immunohistochemistry (negative or 1+) or fluorescent in situ hybridization (FISH)
- No known CNS metastases, even if previously treated
- Hormone receptor status not specified
- PATIENT CHARACTERISTICS:
- Female
- Menopausal status not specified
- WHO performance status 0-1
- LVEF ≥ 55%
- Hemoglobin ≥ 10.0 g/dL
- Absolute neutrophil count ≥ 1,500/mm³
- Platelet count ≥ 100,000/mm³
- Bilirubin \< 2 times upper limit of normal (ULN)
- ALT ≤ 2.5 times ULN (5 times ULN if liver metastases are present)
- Alkaline phosphatase (AP) ≤ 2.5 times ULN
- AP \> 2.5 times ULN and ≤ 6 times ULN allowed if ALT ≤ 1.5 times ULN
- AP \> 6 times ULN allowed if ALT normal
- Creatinine ≤ 1.5 times ULN
- Proteinuria \< 2+ by dipstick OR protein ≤ 1 g/24hr-urine collection
- INR ≤ 1.5 OR Quick ≥ 70%
- aPTT ≤ 1.5 times ULN
- No peripheral neuropathy \> grade 2
- No history or evidence of hereditary bleeding diathesis or coagulopathy with the risk of bleeding
- No uncontrolled hypertension, defined as systolic blood pressure (BP) \> 150 mm Hg and/or diastolic BP \> 100 mm Hg, measured repeatedly at \> 2 visits despite adequate treatment with ≥ 2 different antihypertensive drugs
- No clinically significant cardiovascular disease, including the following:
- Cerebrovascular accident or stroke within the past 6 months
- Myocardial infarction within the past 6 months
- Unstable angina
- New York Heart Association class II-IV congestive heart failure
- Serious cardiac arrhythmia (e.g., ventricular arrhythmia, high-grade atrioventricular-block) not controlled by medication or requiring medication which might interfere with regularity of the study treatment
- No serious nonhealing wound, active peptic ulcer, nonhealing bone fracture, or bleeding skin metastases
- No abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 6 months
- No active infection requiring IV antibiotics
- No known hypersensitivity to any of the study drugs or excipients
- No known hypersensitivity to Chinese hamster ovary cell products or other recombinant human or humanized antibodies
- No evidence of any other disease that contraindicates the use of an investigational drug, that may affect patient compliance with study routines, or places the patient at high risk for treatment-related complications including, but not limited to, the following:
- Metabolic dysfunction
- Physical examination finding
- Psychological dysfunction
- Clinical laboratory finding giving reasonable suspicion of a disease or condition
- No known CNS disease unrelated to cancer (e.g., uncontrolled seizures), unless adequately treated with standard medical therapy
- No high-risk factors for bleeding, including the following:
- Coagulation parameters outside range
- Need for concurrent anticoagulant therapy
- Insufficient time gap after surgical procedures
- No other malignancy within the past 5 years except for adequately treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix
- No significant traumatic injury within the past 28 days
- No known HIV positivity
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception during and for 12 months after completion of study therapy
- PRIOR CONCURRENT THERAPY:
- No prior chemotherapy for metastatic or inoperable locally recurrent breast cancer
- No prior bevacizumab or other anti-vascular endothelial growth factor drug therapy
- No prior radiotherapy involving the heart (usual irradiation dose to breast or chest wall allowed)
- More than 12 months since prior neoadjuvant or adjuvant chemotherapy
- No neoadjuvant or adjuvant doxorubicin hydrochloride with cumulative dose \> 360 mg/m² or epirubicin hydrochloride with cumulative dose \> 720 mg/m²
- More than 6 months since prior adjuvant radiotherapy
- More than 28 days since prior major surgical procedure with high risk of bleeding
- More than 24 hours since prior minor surgical procedures
- More than 10 days since prior acetylsalicylic acid (\> 325 mg/day) or clopidogrel bisulfate (\> 75 mg/day)
- More than 10 days since prior and no concurrent use of full-dose oral or parenteral anticoagulants or thrombolytic agents for therapeutic purposes
- Prophylactic use of anticoagulants allowed (e.g., for maintenance of venous catheter)
- More than 30 days since prior investigational therapies or participation in other investigational studies
- No concurrent hormonal therapy
- No other concurrent antineoplastic or antitumor therapy
- No other concurrent investigational drugs
- No concurrent radiotherapy
- No concurrent nonsteroidal anti-inflammatory drugs with activity on platelets and gastric mucosa (e.g., dipyridamole, clopidogrel bisulfate, acetylsalicylic acid)
- No anticipated need for major surgery during the course of the study treatment
Exclusion
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2009
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT00445406
Start Date
December 1 2006
End Date
March 1 2009
Last Update
June 28 2012
Active Locations (1)
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1
Universitaetsspital-Basel
Basel, Switzerland, CH-4031