Status:
COMPLETED
Abdominal Adiposity and Muscle Mitochondrial Functions
Lead Sponsor:
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Conditions:
Mitochondrial Respiratory Chain Deficiencies
Eligibility:
MALE
35-50 years
Brief Summary
Numerous studies have demonstrated that excess perivisceral adipose tissue is associated with metabolic diseases such as insulin resistance. In skeletal muscle, insulin resistance has been correlated...
Detailed Description
Sixty 35 to 50-years old sedentary men will be included based on their abdominal circumference (from 75 to over 102 cm). Body composition will be evaluated using dual-energy X-ray absorptiometry and ...
Eligibility Criteria
Inclusion
- Male subjects
- Age between 35 and 50
- waist circumference \> 75 cm
- Baecke score \< 1 (activity score for sedentary subjects)
- Subjects giving written informed consent
- Subjects willing to comply with the study procedures
- Subjects considered as normal after clinical examination and medical questionnaire
Exclusion
- Weight change \> 3 kg within 3 months prior to study
- Patients with type 1 or type 2 diabetes
- Serologic evidence of active hepatitis B or HIV
- History of cancer or significant intestinal, hepatic, renal or cardiovascular disorders within the past 5 years
- History of systemic infections or inflammatory diseases within the past 2 months
- Hypocaloric or special diets (e.g. vegetarian)
- Patients currently known to abuse or to be dependent on any drug, including alcohol (daily consumption \> 20g) and tobacco (daily consumption \> 5 cigarettes)
- CRP \< 5 mg/L
- Blood coagulation disorders
- Allergy to xylocaïne
- for test meal : Food allergy (particularly milk allergy and lactose intolerance)
- for MRI : Claustrophobia
Key Trial Info
Start Date :
April 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2007
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00446745
Start Date
April 1 2006
End Date
January 1 2007
Last Update
September 19 2012
Active Locations (1)
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1
Centre ed Recherche en Nutrition Humaine d'Auvergne (CRNH), Unité d'Exploration Nutritionnelle, Laboratoire de Nutrition humaine
Clermont-Ferrand, France, 63009 cedex 1