Status:
UNKNOWN
Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus
Lead Sponsor:
Ruhr University of Bochum
Conditions:
Diabetes Mellitus, Type 2
Eligibility:
All Genders
35-70 years
Phase:
PHASE4
Brief Summary
An AGE-rich diet can induce after 2-6 weeks persistent increases in mediators linked to vascular dysfunction (e.g. TNFα, VCAM-1) in people with type 2 diabetes mellitus (T2DM). Benfotiamine (BT), the ...
Detailed Description
People with type 2 diabetes mellitus (T2DM) have a two to fivefold increase in cardiovascular mortality compared to non-diabetic controls. Endothelial dysfunction (ED) is an early messenger of athero...
Eligibility Criteria
Inclusion
- People with type 2 diabetes mellitus
- Age: 30-70 years
Exclusion
- History of myocardial infarction, stroke within the previous 6 months
- Heart failure NYHA III or more
- Malignant disease
- Severe diabetes complications
- Severe hypo- or hypertension
- Chronic alcohol abuse
- Renal failure (creatinine \>2mg/dl)
Key Trial Info
Start Date :
September 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2008
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00446810
Start Date
September 1 2007
End Date
December 1 2008
Last Update
September 27 2007
Active Locations (1)
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1
Herz- und Diabeteszentrum NRW, Georgstr. 11
Bad Oeynhausen, North Rhine-Westphalia, Germany, 32545